Any body part which is devoid of blood supply may die, and eventually result in gangrene. Gangrene affects the organs that are distant from the heart, which includes toes and fingers. It can affect many other body parts as well, including the vital internal organs. It is considered to be a medical emergency because it may lead to amputations and death. If gangrene is left untreated it can cause shock. It can be life-threatening and requires immediate medical attention. Early recognition and treatment help to reduce complications.

Gas gangrene: Clostridium perfringenis bacterium is the main cause of gas gangrene. The bacteria cause gas bubbles and toxins inside the affected area and the toxic gasses cause tissue death. This is a fatal type of gangrene.